Despite the general parity in the NFL in recent years, there have been many years in which a particular team has been dominant and seemed destined to win it all long before the playoffs began. E.g., '85-86 Bears, '86-87 Giants, numerous 49ers teams, and '99-00 Rams. (Of course, the '98-99 Vikings were the choke exception).
This year, the Colts look invincible. The offense is amazingly consistent, and the defense is well above average. At this point, I would take the Colts against the rest of the league in a Super Bowl bet.